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amoxicillin dose for infants. Might mar 08, 2010i purchased this product and though the safety seal on the outside was intact, the inner seal was broken and inside the cap when i opened. An analytic horizon of 55 years was chosen to include all the future costs and health effects that would have occurred over the life expectancy of the study cohort. amoxicillin decreases the renal clearance of methotrexate, probably by competition at the common tubular secretion system.